立克次氏體3點(diǎn)免疫熒光玻片試劑盒

Rickettsia 3-spot 12-well MIF Substrate Slide

廣州健侖生物科技有限公司

主要用途：用于檢測人血清中的立克次氏體 3 點(diǎn)抗體

產(chǎn)品規(guī)格：12 孔/張,10 張/盒

主要產(chǎn)品包括：包柔氏螺旋體菌、布魯氏菌、貝納特氏立克次體、土倫桿菌、鉤端螺旋體、新型立克次體、恙蟲病、立克次體、果氏巴貝西蟲、馬焦蟲、牛焦蟲、利什曼蟲、新包蟲、弓形蟲、貓流感病毒、貓冠狀病毒、貓皰疹病毒、犬瘟病毒、犬細(xì)小病毒等病原微生物的 IFA、MIF、ELISA試劑。

立克次氏體3點(diǎn)免疫熒光玻片試劑盒

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【公司名稱】 廣州健侖生物科技有限公司
【】    楊永漢 
【】 
【騰訊 】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-3室
【企業(yè)文化】

盡管科學(xué)界對腦卒中的認(rèn)識和治療有著顯著進(jìn)步，但開發(fā)新型和有效的治療方式以對抗這種疾病仍然是一個主要的臨床問題。由腦卒中引起的神經(jīng)組織損傷是因?yàn)檠鞯酱竽X的中斷造成的，并導(dǎo)致葡萄糖，氧和其他營養(yǎng)成分的缺乏。這會導(dǎo)致梗塞核心快速壞死，并形成缺血半影。這種半影可在亞急性期接受干預(yù)治療。在眾多的神經(jīng)變性途徑中，氧化應(yīng)激已被證明可加劇中樞神經(jīng)系統(tǒng)中次級細(xì)胞死亡。
DJ-1是一種多功能氧化還原敏感蛋白，與氧化應(yīng)激的細(xì)胞死亡級聯(lián)相關(guān)。DJ-1提供的神經(jīng)保護(hù)形式可通過多種途徑防止細(xì)胞死亡，zui重要的是通過降低線粒體氧化應(yīng)激和PD聚集蛋白α-突觸核蛋白分子陪伴(作用)，以及刺激抗凋亡和抗氧化基因的表達(dá)，促進(jìn)促生存Akt通路從而阻止細(xì)胞凋亡信號調(diào)節(jié)激酶(ASK1)途徑，并正調(diào)節(jié)雄激素受體依賴性轉(zhuǎn)錄。在細(xì)胞質(zhì)和細(xì)胞核中常見的是，DJ-1可被分泌到病理狀態(tài)下的血清中，還可以通過有絲分裂原刺激轉(zhuǎn)位到各種哺乳動物細(xì)胞的線粒體中，特別令人感興趣的是，氧化應(yīng)激。
來自美國南佛羅里達(dá)大學(xué)醫(yī)學(xué)院Cesar V. Borlongan教授所在團(tuán)隊(duì)討論了其zui近發(fā)現(xiàn)的測試，DJ-1不僅可以作為氧化應(yīng)激的細(xì)胞內(nèi)保護(hù)的一種形式，也利用它從旁分泌和/或自分泌線索以完成相鄰神經(jīng)細(xì)胞之間的細(xì)胞外信號傳導(dǎo)從而達(dá)到神經(jīng)保護(hù)作用。相關(guān)研究內(nèi)容發(fā)表在2014年8月第15期《中國神經(jīng)再生研究(英文版)》雜志上。

Despite significant advances in the understanding and treatment of stroke in the scientific community, developing new and effective treatments to combat the disease remains a major clinical problem. Nerve tissue damage caused by stroke is caused by a breakdown of blood flow to the brain and results in a lack of glucose, oxygen and other nutrients. This can lead to rapid necrosis of the infarct core and the formation of ischemic penumbra. This penumbra can be sub-acute intervention in the treatment. Among numerous neurodegeneration pathways, oxidative stress has been shown to exacerbate secondary cell death in the central nervous system.
DJ-1 is a multifunctional redox-sensitive protein that is associated with a cascade of oxidative stress. The neuroprotective form provided by DJ-1 can prevent cell death through a variety of pathways, most importantly by reducing mitochondrial oxidative stress and companion (action) of the PD aggregin alpha-synuclein molecule as well as stimulating anti-apoptotic and anti- Oxidative gene expression promotes the pro-survival Akt pathway thus blocking the apoptotic signal-regulated kinase (ASK1) pathway and up-regulating androgen receptor-dependent transcription. It is common in the cytoplasm and nucleus that DJ-1 can be secreted into the serum under pathological conditions and can also be stimulated to translocate to the mitochondria of various mammalian cells by mitogens. Of particular interest is the oxidation of Stress.
The team from Professor Cesar V. Borlongan, University of South Florida School of Medicine, USA, discussed his recently discovered test that DJ-1 can be used not only as a form of intracellular protection of oxidative stress, but also from paracrine and / or Secretion of clues to complete the extracellular signal transduction between adjacent nerve cells to achieve neuroprotective effect. Relevant research is published in the 15th issue of "Chinese Journal of Nervous Regeneration Research (English Edition)" in August 2014.